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Hereditary Spherocytosis Smear - Hereditary Spherocytosis | Medical Laboratories : Genetic mutations in the vertical protein linkages between the membrane and cytoskeleton: . Patients can also have pseudohyperkalemia. Several cases have been misdiagnosed in the past with the Hereditary spherocytosis forms having different membrane defects can show different red cell morphologies. Hereditary spherocytosis patients with spherocytes on the peripheral smear who have a family history of hereditary spherocytosis, clinical features consistent with this disorder, an increased mean corpuscular hemoglobin concentration (mchc), and reticulocytosis do not require any additional testing. A family history of hs, early splenectomy, or gall bladder disease. Hereditary spherocytosis patients with spherocytes on the peripheral smear who have a family history of hereditary spherocytosis, clinical features consistent with this disorder, an increased mean corpuscular hemoglobin concentra...